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| 英文名称 | Thyroglobulin |
| 中文名称 | 甲状腺球蛋白抗体 |
| 别 名 | TG; AITD 3; AITD3; hTG; TDH3; Tg; Tgn; THYG_HUMAN. |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Rat, (predicted: Human, Mouse, Dog, Pig, Cow, Cat, ) |
| 产品应用 | ELISA=1:2000-10000 IHC-P=1:200-1000 IHC-F=1:200-1000 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 660kDa |
| 细胞定位 | 分泌型蛋白 |
| 性 状 | Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | Thyroglobulin protein:full length |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | Thyroglobulin is the glycoprotein precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is obtained from the thyroid gland and exhibits the general properties of the globulins. The human thyroglobulin (hTG) is a high molecular weight glycoprotein (605 kDa) found in the thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones, T4 and T3. Thyroid disorders are, in large part, due to autoimmune origin, and anti thyroglobulin autoantibodies were the first factor to be discovered. Anti hTG is found in all thyroid autoimmune diseases (Hashimoto's thyroiditis, Graves' diseases), with the highest level observed in Hashimoto's thyroiditis. Anti hTG is also characteristic of thyroid cancer, and its determination can be used for the follow up of cancer patients. Function: Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Subunit: Homodimer. Subcellular Location: Secreted. Tissue Specificity: Thyroid gland specific. Post-translational modifications: Sulfated tyrosines are desulfated during iodination. DISEASE: Defects in TG are the cause of thyroid dyshormonogenesis 3 (TDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases. Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection. Similarity: Belongs to the type-B carboxylesterase/lipase family. Contains 11 thyroglobulin type-1 domains. SWISS: P01266 Gene ID: 7038 Database links: Entrez Gene: 7038 Human Entrez Gene: 21819 Mouse Entrez Gene: 24826 Rat Omim: 188450 Human SwissProt: P01266 Human SwissProt: O08710 Mouse SwissProt: P06882 Rat Unigene: 654591 Human Unigene: 441333 Mouse Unigene: 10429 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |  Paraformaldehyde-fixed, paraffin embedded (rat ovary); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TG) Polyclonal Antibody, Unconjugated (0291R) at 1:400 overnight at 4°C, followed by a conjugated secondary (0023) for 20 minutes and DAB staining. |
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