肿瘤坏死因子受体2抗体

 英文名称 TNFR2

中文名称 肿瘤坏死因子受体2抗体

别    名  TNF Receptor II; CD120b; p75; p75TNFR; p80 TNF alpha receptor; p80 TNF-alpha receptor; TBP-2; TBPII; TNF R2; TNF R75; TNF-R2; TNF-RII; TNFR-II; TNFR80; TNFRII; TNFRSF1B; TNR1B_HUMAN; Tumor necrosis factor receptor 2; Tumor necrosis factor receptor type II; Tumor necrosis factor-binding protein 2.  

研究领域 肿瘤  细胞生物  神经生物学  信号转导  细胞凋亡  细胞膜受体  

抗体来源 Rabbit

克隆类型 Polyclonal

交叉反应 Human, Mouse, 

产品应用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量 46kDa

细胞定位 细胞膜 分泌型蛋白 

性    状 Liquid

浓    度 1mg/ml

免 疫 原 KLH conjugated synthetic peptide derived from human TNFR2:201-300/461

亚    型 IgG

纯化方法 affinity purified by Protein A

储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍 The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]

 

Function:

Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

 

Subcellular Location:

Secreted and Cell membrane.

 

Post-translational modifications:

Phosphorylated; mainly on serine residues and with a very low level on threonine residues.

A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.

 

Similarity:

Contains 4 TNFR-Cys repeats.

 

SWISS:

P20333

 

Gene ID:

7133

 

Database links:

Entrez Gene: 7133 Human

 

Entrez Gene: 21938 Mouse

 

Entrez Gene: 156767 Rat

 

Omim: 191191 Human

 

SwissProt: P20333 Human

 

SwissProt: P25119 Mouse

 

SwissProt: Q80WY6 Rat

 

Unigene: 256278 Human

 

Unigene: 235328 Mouse

 

Unigene: 83633 Rat

 

 

 

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.