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Product Details
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant (partial) (308-524aa)
- Formulation
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0.5 mg/ml.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, store undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
ICC, ChIP - Verified
IP - Reported in the literature, not verified in house - Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 5 ?g per 5 ml antibody dilution buffer for each mini-gel. For ChIP applications, the suggested dilution is 1:50-1:200 by volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
10D1 displayed a stronger affinity for SSRP1 than BioLegend clone 3E4 when tested for western blot application.
- Application References
(PubMed link indicates BioLegend citation) -
- Tan BC, et al. 2006. EMBO 25:3975. (ChIP)
- Carvalho S, et al. 2013. Nucleic Acids Res. 41:2881. PubMed
- Tan BC, et al. 2004. J. Biol. Chem. 279:9321. (Immunogen)
- Lolis AA, et al. 2013. J Biol Chem. 288:7676. PubMed
- Aida M, et al. 2013. PNAS. 110:7784. PubMed
- Dermawan JK, et al. 2014. Mol Cancer Ther. 13:2203. PubMed
- Shakya A, et al. 2015. Mol Cell Biol. 35:1014. PubMed
- Product Citations
-
- RRID
- AB_315730 (BioLegend Cat. No. 609701) AB_315731 (BioLegend Cat. No. 609702)
Antigen Details
- Structure
- SSRP family, HMG box domain; 81 kD
- Distribution
-
Nuclear
- Function
- Interacts with nucleosomes and histone H2A/H2B dimers to promote nucleosome disassembly and allow transcription elongation, binds to dsDNA. Modified by cisplatin, may protect DNA from repair and block DNA replication
- Interaction
- Component of FACT ATP-dependent chromatin remodeling complex, SUPT16H/Cdc68 in FACT complex, H2A/H2B dimers
- Biology Area
- Cell Biology, Chromatin Remodeling/Epigenetics, DNA Repair/Replication, Transcription Factors
- Antigen References
-
1. LeRoy G, et al. 1998. Science 282:1836.
2. Orphanides G, et al. 1998. Cell 92:105.
3. Orphanides G, et al. 1999. Nature 400:284. - Gene ID
- 6749 View all products for this Gene ID
- UniProt
- View information about SSRP1 on UniProt.org
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