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Product Details
- Verified Reactivity
- Human
- Reported Reactivity
- African Green, Baboon, Cynomolgus, Rhesus
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- L-cells transfected with human α9
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
Additional reported application (for the relevant formats) include: immunofluorescence microscopy1, immunopricipitation2, and blocking3.
- Application References
(PubMed link indicates BioLegend citation) -
- Lafuste P, et al. 2005. Mol. Biol. Cell. 16:861. (IF)
- Chen C, et al. 2006. Immunity 25:895. (FC, IP)
- Taooka Y, et al. 1999. J. Cell Biol. 145:413. (Block)
- Product Citations
-
- RRID
- AB_10720186 (BioLegend Cat. No. 351605) AB_10719961 (BioLegend Cat. No. 351606)
- Disclaimer
This product is for in vitro research use only. It is not to be used for commercial purposes. Use of this product to produce products for sale or for diagnostic, therapeutic or drug discovery purposes is prohibited. In order to obtain a license to use this product for commercial purposes, contact The Regents of the University of California.
Antigen Details
- Structure
- Heterodimeric proteins made up of α9 and β1 subunits
- Distribution
-
Neutrophil, monocytes, endothelial cells, hepatopoietic cells, and different type of muscle cells
- Function
- Receptor for VCAM-1, involved in cell adhesion and migration
- Interaction
- Recognizes α9 integrin expressed as a heterodimer in association with the β1 integrin.
- Ligand/Receptor
- VCAM-1, ECM proteins tenascin C, osteopontin
- Cell Targets
- Binds VCAM-1
- Cell Type
- Endothelial cells, Monocytes, Neutrophils
- Biology Area
- Cell Adhesion, Cell Biology, Immunology, Innate Immunity, Neuroscience, Synaptic Biology
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
-
1. Schreiber TD, et al. 2009 Haematologica 94:1495.
2. Chen C, et al. 2006 Immunity 25:895.
3. Taooka Y, et al. 1999 J. Cell Biol. 145:413.
4. Palmer EL, et al. 1993 J. Cell Biol. 123:1289. - Gene ID
- 3680 View all products for this Gene ID 3688 View all products for this Gene ID
- UniProt
- View information about Integrin alpha9 beta1 on UniProt.org
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