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PE anti-mouse TCR Vβ5.1, 5.2 Antibody

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Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Murine T cell hybridoma 2HB51.8
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume.? It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: Induction of proliferation of V?5.1+ and V?5.2+ T cells2, 3 and in vivo depletion of V?5+ T cells4.

Application References

(PubMed link indicates BioLegend citation)
  1. Kanagawa O, et al. 1991. J. Immunol. 147:1307. (FC)
  2. Kanagawa O, et al. 1992. J. Immunol. 149:9. (Activ)
  3. Woodland DL, et al. 1993. J. Exp. Med. 177:433. (Activ)
  4. Gelber C, et al. 1992. Cancer Res. 52:6507. (Deplete)
Product Citations
  1. Lancaster JN, et al. 2019. Nat Commun. 10:2220. PubMed
  2. Takeda Y, et al. 2018. Innate Immun. 24:323. PubMed
  3. Okuniewska M, et al. 2021. Cell Reports. 36(2):109368. PubMed
  4. Prasad M, et al. 2021. Front Immunol. 12:644483. PubMed
  5. Hojo MA, et al. 2019. Nat Commun. 2.224305556. PubMed
  6. Russler-Germain EV, et al. 2021. Elife. 10:. PubMed
  7. Kondo M, et al. 2016. J Immunol. 196: 563 - 572. PubMed
  8. Morris AB, et al. 2020. Immunity. 52(1):136-150.e6.. PubMed
  9. Wang X, et al. 2022. Elife. 11:. PubMed
RRID
AB_10612761 (BioLegend Cat. No. 139503) AB_10613279 (BioLegend Cat. No. 139504)

Antigen Details

Structure
Member of the immunoglobulin superfamily, Vβ5.1and 5.2 are variants of the TCR β chain which associates with the TCR α chain to form the TCR heterodimer.
Distribution

Expressed on a subset of TCR αβ+ T cells.

Function
Recognition of peptides presented by the MHC molecules, responsible for T cell mediated immune responses.
Ligand/Receptor
MHC-Peptide complex
Cell Type
T cells
Biology Area
Adaptive Immunity, Immunology
Molecular Family
TCRs
Antigen References

1. Marrack P, et al. 2008. Annu. Rev. Immunol. 26:171. 
2. Sim GK and Augustin AA. 1985. Cell 42:89. 
3. Mami-Chouaib F, et al. 2002. Immunol. Rev. 188:114.

Gene ID
21577 View all products for this Gene ID
UniProt
View information about TCR Vb5.1, 5.2 on UniProt.org
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