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| 中文名称 | 整合素相关蛋白CD47 |
| 研究领域 | 肿瘤 神经生物学 细胞粘附分子 | ||
| 抗体来源 | Rabbit | ||
| 克隆类型 | Polyclonal | ||
| 交叉反应 | Human, Mouse, Rat, (predicted: Rabbit, ) | ||
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=2μg/Test IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. | ||
| 理论分子量 | 33kDa | ||
| 检测分子量 | 42-52 kDa | ||
| 细胞定位 | 细胞膜 | ||
| 性 状 | Liquid | ||
| 浓 度 | 1mg/ml | ||
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD47/MER6: 241-323/323 | ||
| 亚 型 | IgG | ||
| 纯化方法 | affinity purified by Protein A | ||
| 缓 冲 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. | ||
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. | ||
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. | ||
| PubMed | PubMed | ||
| 产品介绍 | This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010] Function: Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection. Subunit: Interacts with THBS1 and fibrinogen (By similarity). Monomer. Interacts with SIRPA, SIRPG, UBQLN1 and UBQLN2. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain. Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain. SWISS: Q08722 Gene ID: 961 Database links: Entrez Gene: 961 Human Entrez Gene: 16423 Mouse SwissProt: Q08722 Human SwissProt: Q61735 Mouse Unigene: 446414 Human Unigene: 31752 Mouse Unigene: 390865 Mouse Unigene: 7409 Rat
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