端粒酶相关蛋白1抗体

英文名称：端粒酶相关蛋白1抗体
产品类别：抗体
产品编号：TEP1

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50ul

￥ 1200 6

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100ul

￥ 1900 3

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英文名称	TEP1
中文名称	端粒酶相关蛋白1抗体
别名	Telomerase Associated pratein-1; TEP1; TLP1; TP1 TP-1; Telomerase protein component 1; Telomerase protein 1; p240; p80 telomerase homolog; TEP1_HUMAN; Telomerase associated protein 1; Telomerase protein component 1; TROVE domain family, member 1; TROVE1; VAULT2.
研究领域	神经生物学信号转导
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	(predicted: Human, Mouse, Rat, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
理论分子量	290kDa
细胞定位	细胞核
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human TP-1: 1701-1800/2627
亚型	IgG
纯化方法	affinity purified by Protein A
缓冲液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
产品介绍	Telomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase-associated protein 1 (TEP1). Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death. High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TEP1 do not correlate with malignancy. At least two isoforms of TP1 are known to exist. Function: Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity). Subunit: Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). Subcellular Location: Nucleus (Probable). Telomere. Tissue Specificity: Ubiquitous. Similarity: Contains 1 NACHT domain. Contains 4 TEP1 N-terminal repeats. Contains 1 TROVE domain. Contains 21 WD repeats.