文章标题：Exploration of the mechanism of Qi-Xian decoction in asthmatic mice using metabolomics combined with network pharmacology
作者列表：Yuhua Lin, Yue Wu, Fuqi Ma, Cuiting Shan, Jialu Ma, Wenguan Li, Huayang Pan, Xiayi Miao, Jinjin Liu, Xiongbiao Wang, Zhenhua Ni
影响因子：5
期刊：Frontiers in Molecular Biosciences
发表时间：2023-12-13
DOI:10.3389/fmolb.2023.1263962
文献主题：
Abstract
Introduction: Qi-Xian Decoction (QXD), a traditional Chinese medicine (TCM) formula consisting of eight herbs, has been clinically used to treat asthma. However, the underlying mechanisms have not been completely elucidated. This study aimed to combine metabolomics and network pharmacology to reveal the mechanism of action of QXD in asthma treatment.
Methods: An ovalbumin (OVA)-induced asthma mouse model was constructed to evaluate the therapeutic effects of QXD. Serum metabolomics and network pharmacology were combined to study the mechanism of anti-asthma action as well as the potential target, and related biological functions were validated.
