文章标题：Excessive Supplement of l-Arginine Induces Myopia via Orchestrating the MEK-ERK-NO Signaling Pathway
影响因子：5.7
期刊：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
作者列表：Bo Bao, Jinpeng Liu, Jizhao Xin, Xiangkun Zhou, Ruixue Zhang, Jiawen Hao, Zhaohui Yang, Miao Zhang, Zhongyu Ma, Xuewei Yin, Hongsheng Bi, Dadong Guo
发表时间：2024-11-13
DOI:10.1021/acs.jafc.4c09346
主要研究成果：Myopia can impact an individual’s quality of life and induce multiple complications. In this study, we randomly divided guinea pigs into the normal control (NC) group, the lens-induced myopia (LIM) group, the normal control plus l-arginine injection (l-Arg) group, and the normal control plus saline injection (NaCl) group. The animals in each group received the relevant treatments. The results showed that myopia was deeper in the LIM and l-Arg groups compared with the NC and NaCl groups. Our experimental results suggest that the excessive supplement of l-Arg will induce myopia onset and a MEK-ERK cascade that stimulates the downstream nNOS-MMP2 and NRF2-KEAP1 signaling pathways, which is accompanied by inflammatory responses, fibrosis changes, and oxidative stress. After receiving excessive arginine supplements, the experimental individuals showed myopic shifts and a similar pathological state as the LIM group. In conclusion, the supplement of excessive arginine may be a danger factor for myopia onset.
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