人内源性逆转录病毒H长末端重复相关蛋白2抗体

产品价格：￥ 1680
英文名称：HHLA2
产品类别：抗体
产品编号：Ys-8419R
保存条件：Shipped at 4℃. Store at -20 °C for one year. Avoid

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英文名称 HHLA2

中文名称人内源性逆转录病毒H长末端重复相关蛋白2抗体

别名 Human endogenous retrovirus H long terminal repeat associating protein 2; HERV H LTR associating 2; HERV-H LTR-associating protein 2; HHLA 2; HHLA2; HHLA2_HUMAN; Human endogenous retrovirus-H long terminal repeat-associating protein 2.

研究领域细胞生物免疫学转录调节因子

抗体来源 Rabbit

克隆类型 Polyclonal

交叉反应 Human,

产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分子量 45kDa

细胞定位细胞膜

性状 Liquid

浓度 1mg/ml

免疫原 KLH conjugated synthetic peptide derived from human HHLA2:231-330/414

亚型 IgG

纯化方法 affinity purified by Protein A

储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍 Human endogenous retroviruses (HERVs) are repetitive elements that are derived from ancient germline retroviral infections. Due to their ability to move and insert next to certain genes and alter expression patterns, HERVs have been linked to several chronic diseases such as nervous systemic diseases, cancer, autoimmune and connective tissue diseases. The HERV-H family is the most abundant HERV family and has been implicated in the expression of a variety of adjacent genes. Proteins belonging to the HERV-H family are divided into one major and two minor groups based on sequence divergence. As a member of the HERV-H family, HHLA2 (HERV-H LTR-associating protein 2) is a 414 amino acid single-pass type I membrane protein that contains one Ig-like C1-type (immunoglobulin-like) domain and two Ig-like V-type (immunoglobulin-like) domains. HHLA2 is primarily expressed in kidney, lung and intestinal tissues.

Subcellular Location:

Membrane; Single-pass type I membrane protein (By similarity).

Tissue Specificity:

Expressed in colon, small intestine, lung and kidney.

Similarity:

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Contains 2 Ig-like V-type (immunoglobulin-like) domains.

SWISS:

Q9UM44

Gene ID:

11148

Database links:

Entrez Gene: 11148 Human

Omim: 604371 Human

SwissProt: Q9UM44 Human

Unigene: 252351 Human

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品图片

Sample:
MDA-MB-231(Human) Cell Lysate at 30 ug
Primary: Anti-HHLA2 (ys-8419R) at 1/500 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 45 kD
Observed band size: 60 kD

Sample:
LOVO(Human) Cell Lysate at 30 ug
A549(Human) Cell Lysate at 30 ug
Primary: Anti-HHLA2 (ys-8419R) at 1/500 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 45 kD
Observed band size: 50kD