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| 产品编号 | bs-43191P |
| 英文名称 | Recombinant human F2 protein, C-His (HEK293) |
| 中文名称 | 重组人异常凝血酶原/脱-γ-羧基凝血酶原蛋白 |
| 别 名 | Des-gamma-carboxy (abnormal)prothrombin; Des-Gamma-carboxy-prothrombin; coagulation factor II (thrombin); Coagulation factor II; DCP; Factor II; Prepro coagulation factor II; Prothrombin; prothrombin B-chain; PT; RPRGL2; serine protease; THPH1; THRB; THRB_HUMAN; Thrombin heavy chain. |
| 理论分子量 | 31.6kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | >0.5mg/ml |
| 物 种 | Human |
| 纯 度 | >90% as determined by SDS-PAGE |
| 纯化方法 | AC |
| 内毒素 | Not analyzed |
| 表达系统 | HEK293 cell |
| 标签 | C-His |
| 缓 冲 液 | PBS (pH=7.4) |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 | Des-gamma carboxyprothrombin (DCP), also known as protein induced by vitamin K absence/antagonist-II (PIVKA-II), is an abnormal form of the coagulation protein, prothrombin. Normally, the prothrombin precursor undergoes post-translational carboxylation (addition of a carboxylic acid group) by gamma-glutamyl carboxylase in the liver prior to secretion into plasma. DCP/PIVKA-II may be detected in people with deficiency of vitamin K (due to poor nutrition or malabsorption) and in those taking warfarin or other medication that inhibits the action of vitamin K. SWISS: P00734 Gene ID: 2147 正常肝细胞中，在内质网内可将DCP羧化使之成为有活性的凝血酶原，一旦机体需要，凝血酶原即可转变成凝血酶参与机体的各项生理功能，当有肿瘤细胞发生时，DCP明显升高。DCP主要用于肝癌方面的研究；有学者认为：联合应用DCP和AFP对于早期诊断HCC（原发性肝细胞癌）有较大的帮助。 |
| 产品图片 |  The purity of the protein is greater than 85% as determined by reducing SDS-PAGE. |
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