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重组人细胞核因子/k基因结合核因子蛋白

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产品编号bs-42286P
英文名称Recombinant human NFKB p65 protein, N-GST
中文名称重组人细胞核因子/k基因结合核因子蛋白
别    名kB P65; NF-kB p65; NFKBp65; NF-κBp65; NF-kBp65; Avian reticuloendotheliosis viral (v rel) oncogene homolog A; MGC131774; NFKB 3; NFKB3; Nuclear Factor NF Kappa B p65 Subunit; Nuclear factor of kappa light polypeptide gene enhancer in B cells 3; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B Cells; p65; p65 NF kappaB; p65 NFkB; RELA; Transcription Factor p65; v rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B cells 3 (p65)); V Rel Avian Reticuloendotheliosis Viral Oncogene Homolog A; v rel reticuloendotheliosis viral oncogene homolog A (avian); v-rel reticuloendotheliosis viral oncogene homolog A; p65NFKB; TF65_HUMAN.  
理论分子量62.5kDa
性    状Lyophilized or Liquid
浓    度>0.5mg/ml
物    种Human
序    列1-306/551
纯    度>90% as determined by SDS-PAGE
纯化方法AC
内毒素Not analyzed
表达系统E.coli
标签N-GST
缓 冲 液50mM Tris-Hcl (pH=8.0) with 10mM GSH
保存条件Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.
注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].

SWISS:
Q04206

Gene ID:
5970

转录调节因子(Transcriptin Regulators)
NF-κBp65是一种重要的转录因子,NF-kBp65可激活参与炎症、细胞增殖、细胞凋亡等基因的调节,影响着细胞的凋亡,同时影响着肿瘤细胞对细胞毒性药物及离子辐射的敏感性。ras基因诱导的致癌突变作用需NFkB的活化,提示NFkB在致癌发生方面可能起一定作用;另有文献报道,在乳腺癌、非小细胞性肺癌、甲状腺癌、T或B淋巴细胞白血病及病毒诱变导致的肿瘤等人类肿瘤中,NFkB活化或表达。
经研究认为:NFKBp65蛋白在静息状态下以结合态的方式存在于胞浆中,当NFKBp65蛋白被激活后解离进入细胞核。(NF-κB与其抑制蛋白IκB家族成员结合,以无活性的复合物形式存在于胞浆中,当细胞受到各种刺激后,NF- κB与IκB 解离,从而进入细胞核,与相应的靶序列结合,调节基因的表达)
产品图片
The purity of the protein is greater than 85% as determined by reducing SDS-PAGE.
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