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| 产品编号 | bs-43637P |
| 英文名称 | Recombinant human NGFR protein, C-His (HEK293) |
| 中文名称 | 重组人神经生长因子受体蛋白 |
| 别 名 | TNR16_HUMAN; Tumor necrosis factor receptor superfamily member 16; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor (NGF receptor 1 Publication); p75 ICD; CD271; TNFRSF16; p75NTR; p75(NTR); Gp80-LNGFR; p75 NGF Receptor; |
| 理论分子量 | 25.8kDa |
| 性 状 | Liquid |
| 浓 度 | >1mg/ml |
| 物 种 | Human |
| 序 列 | 29-250/427 |
| 纯 度 | >90% as determined by SDS-PAGE |
| 纯化方法 | AC |
| 内毒素 | Not analyzed |
| 表达系统 | HEK293 cell |
| 标签 | C-His |
| 缓 冲 液 | PBS (pH=7.4) |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 | The low affinity NGFR (Nerve growth factor receptor) is a 75kDa membrane-spanning glycoprotein lacking intrinsic tyrosine kinase activity. p75NGFR interacts with TrkA, the high affinity NGF receptor and potentiates TrkA signaling at low NGF concentrations. The p75 receptor binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NGFR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death. It is expressed on many neuronal cells types including many embryonic forms and the receptor can be used to isolate neuronal progenitor cells. NGF is important for the development, differentiation and survival of a variety of neuronal and non-neuronal cells. Its action is mediated by binding to two distinct receptors, the high affinity p140 and low affinity p75. p75NGFR binds neurotrophins including brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), NT-4/5, and NT-6. p75NGFR belongs to the TNF-R superfamily and is reported to mediate NGF-induced apoptosis. SWISS: P08138 Gene ID: 4804 神经生物学相关蛋白（Neurobiology） NGFR神经生长因子受体又称：CD271存在与细胞上的与神经生长因子相结合并相互作用的蛋白质因子，属一型跨膜TNF受体超家族糖蛋白，它可与NGF, BDNF, NT-3, NT-4 结合，根据与神经生长因子的结合力速度及亲和力可分为高亲和力和低亲和力两种NGFR。 此抗体识别分子量为47kDa低亲和力的NGFR.NGF-R也称为低亲和神经生长因子受体，属1型跨膜TNF受体超家族。 |
| 产品图片 |  The purity of the protein is greater than 90% as determined by reducing SDS-PAGE. |
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