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| 产品编号 | bs-42194P |
| 英文名称 | Recombinant human OST-beta protein, N-GST |
| 中文名称 | 重组人有机溶质转运蛋白OSTβ蛋白 |
| 别 名 | organic solute transporter beta (Ostbeta); Organic solute transporter subunit beta; Ostbeta; Ost beta; OSTB; OSTB_HUMAN. |
| 理论分子量 | 35.5kDa |
| 性 状 | Liquid |
| 浓 度 | >1mg/ml |
| 物 种 | Human |
| 序 列 | 57-128/128 |
| 纯 度 | >90% as determined by SDS-PAGE |
| 纯化方法 | AC |
| 内毒素 | Not analyzed |
| 表达系统 | E.coli |
| 标签 | N-GST |
| 缓 冲 液 | PBS (pH=7.4) with 15mM GSH |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 | The heteromeric transporter OST Alpha/OST Beta facilitates the transport of bile and other steroid solutes across the basolateral epithelial cell membrane of intestine, liver, testis, kidney and adrenal gland. OST Alpha/OST Beta expression is induced by bile acids through ligand-dependent transactivation of their genes by FXR (Farnesoid X-activated receptor). This genetic regulation suggests that in response to changes in intracellular bile acid levels, bile acids adjust the rate of their own efflux from enterocytes. OST Beta is a 128 amino acid single-pass transmembrane protein that requires OST Alpha to localize to the plasma membrane. Coexpression of OST Alpha and OST Beta is also required to convert the OST Alpha subunit to a mature glycosylated endoglycosidase H-resistant form, suggesting that co-expression facilitates trafficking of OST Alpha through the golgi apparatus. Though widely expressed, OST Beta is present at highest levels in ileum. SWISS: Q86UW2 Gene ID: 123264 |
| 产品图片 |  The purity of the protein is greater than 90% as determined by reducing SDS-PAGE. |
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