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中文名称
重组人环氧合酶2/前列腺素内过氧化物合成酶2蛋白
英文别名
Recombinant human COX2 protein, His
性状
Liquid
纯化方法
AC
理论分子量
35
检测分子量
35 kDa
浓度
＞0.5 mg/ml
储存液
20mM Tris-HCl (pH8.0) 0.02% Proclin300 with 10% Glycerol.
研究领域
Cancer > Cancer Metabolism > Metabolic signaling pathway > Hormone biosynthesis
Cancer > Tumor biomarkers
Cardiovascular > Atherosclerosis > Lipoprotein metabolism
Cardiovascular > Blood > Platelets
Cardiovascular > Lipids / Lipoproteins > Lipid Metabolism > Cholesterol Metabolism
Immunology > Innate Immunity > Macrophage / Inflamm.
Metabolism > Pathways and Processes > Endocrine metabolism > Hormone biosynthesis
Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Cholesterol Metabolism
Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipoprotein metabolism
Metabolism > Types of disease > Heart disease
Signal Transduction > Signaling Pathway > Lipid Signaling > Prostaglandins
亚基
Homodimer.
亚细胞定位
Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Post-translational modifications : S-nitrosylation by NOS2 (iNOS) activates enzme activity. S-nitrosylation may take place on different Cys residues in addition to Cys-561.
翻译后修饰
S-nitrosylation by NOS2 (iNOS) activates enzme activity. S-nitrosylation may take place on different Cys residues in addition to Cys-561.
相似性
Belongs to the prostaglandin G/H synthase family. Contains 1 EGF-like domain.
活性
Not tested
序列
300-604/604
标签
His
纯度
>95% as determined by SDS-PAGE
内毒素
Not analyzed
表达系统
E.coli
复溶
Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
功能
Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.
保存条件
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]
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